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AGE is an extract from garlic powder in a non-toxic solvent

Interestingly, all-trans retinoic acid (ATRA), an inhibitor of Pin1, inhibits the drug resistance of cells mainly by inhibiting the ERK 1/2 and AKT pathways ( Inhibition of epithelialmesenchymal transition (EMT)-like phenomena is also a direction to take to overcome drug resistance

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doi:10.1016/j.clinph.2014.12.021 Oghalai JS, Manolidis S, Barth JL, Stewart MG, Jenkins HA

Reference: Hsieh et al., 2017 (VEGFR2AkteNOS signalling involvement) VEGFR2 activation triggers: VEGF binding VEGFR2 autophosphorylation (turns on VEGFR2) which leads to PI3K activation which leads to Akt phosphorylation Akt (Protein Kinase B) is critical because it phosphorylates (turns on) eNOS which leads to Nitric oxide synthesis more nitric oxide